{"id":20668,"date":"2019-08-21T09:54:09","date_gmt":"2019-08-21T01:54:09","guid":{"rendered":"http:\/\/www.shineu.com\/?p=20668"},"modified":"2019-08-21T09:54:09","modified_gmt":"2019-08-21T01:54:09","slug":"%e9%85%92%e5%96%9d%e5%a4%9a%e4%ba%86%e4%bc%9a%e5%8f%98%e5%82%bb%ef%bc%811%e4%b8%87%e4%ba%ba23%e5%b9%b4%e9%9a%8f%e8%ae%bf%e7%a0%94%e7%a9%b6%e6%8f%ad%e5%bc%80%e7%9c%9f%e7%9b%b8","status":"publish","type":"post","link":"https:\/\/www.shineu.com\/20668.html","title":{"rendered":"\u9152\u559d\u591a\u4e86\u4f1a\u53d8\u50bb\uff011\u4e07\u4eba23\u5e74\u968f\u8bbf\u7814\u7a76\u63ed\u5f00\u771f\u76f8"},"content":{"rendered":"
\u7591\u95ee\uff1a\u6240\u8c13\u9002\u91cf\u7a76\u7adf\u662f\u591a\u5c11\uff1f\u8bc1\u636e\uff1a\u559d\u592a\u591a\u9152\u4f1a\u628a\u4eba\u559d\u50bb\uff01\u5efa\u8bae\uff1a\u6ca1\u4e8b\u513f\u8fd8\u662f\u60a0\u7740\u70b9\u513f\u2026<\/p>\n
\u7591\u95ee<\/strong><\/p>\n \u6240\u8c13\u9002\u91cf\u7a76\u7adf\u662f\u591a\u5c11\uff1f<\/strong><\/p>\n \u5c3d\u7ba1\u4e0d\u662f\u4eba\u4eba\u90fd\u4e60\u60ef\u4e8e\u559d\u9152\uff0c\u4f46\u4e16\u754c\u5404\u5730\u51e0\u4e4e\u4e0d\u5b58\u5728\u6ca1\u6709\u559d\u8fc7\u9152\u7684\u4eba\u3002\u9ad8\u5174\u4e86\u8981\u5f00\u6000\u7545\u996e\uff0c\u4f24\u5fc3\u4e86\u501f\u9152\u6d47\u6101\uff0c\u751a\u81f3\u6709\u4e0d\u5c11\u4eba\uff0c\u5e73\u65e5\u91cc\u4e5f\u79bb\u4e0d\u5f00\u9152\uff0c\u5e38\u5e38\u501f\u7740\u6d3b\u8840\u3001\u4fdd\u5065\u7684\u540d\u4e49\u559d\u4e0a\u4e00\u676f\u3002<\/p>\n \u996e\u9152\u5bf9\u4e8e\u75f4\u5446\u7684\u5f71\u54cd\u4e5f\u9887\u53d7\u4eba\u4eec\u7684\u5173\u6ce8\u3002\u968f\u7740\u4eba\u7c7b\u9884\u671f\u5bff\u547d\u7684\u4e0d\u65ad\u589e\u957f\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8001\u5e74\u4eba\u5c06\u4f1a\u53d7\u5230\u75f4\u5446\u7684\u56f0\u6270\u3002\u636e\u4f30\u8ba1\uff0c\u5230\u4e862050\u5e74\uff0c\u5168\u7403\u75f4\u5446\u75c7\u7684\u60a3\u75c5\u7387\u5c06\u4f1a\u589e\u52a03\u500d\uff0c\u60a3\u75c5\u4eba\u6570\u5c06\u8fbe1.35\u4ebf\uff0c\u4f46\u996e\u9152\u4e0e\u75f4\u5446\u7684\u5173\u7cfb\u8fd8\u4e0d\u592a\u6e05\u6670[2]\u3002<\/p>\n \u25cf \u6709\u4e00\u4e9b\u7814\u7a76\u63d0\u793a\uff0c\u9002\u91cf\u996e\u9152\u53ef\u80fd\u4f1a\u964d\u4f4e\u75f4\u5446\u98ce\u9669\uff0c\u4f46\u6240\u8c13\u7684\u201c\u9002\u91cf\u201d\u7a76\u7adf\u662f\u591a\u5c11\uff1f<\/p>\n \u25cf \u8bb8\u591a\u7814\u7a76\u4ec5\u4ec5\u63a2\u7d22\u4e86\u8001\u5e74\u671f\u996e\u9152\u91cf\u4e0e\u75f4\u5446\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u4f46\u75f4\u5446\u7684\u53d1\u5c55\u662f\u4e2a\u7f13\u6162\u7684\u8fc7\u7a0b\uff0c\u4ee5\u524d\u559d\u7684\u9152\u53ef\u4e0d\u80fd\u4e00\u7b14\u52fe\u9500\uff01<\/p>\n \u25cf \u996e\u9152\u548c\u75f4\u5446\u4e4b\u95f4\u6251\u6714\u8ff7\u79bb\u7684\u5173\u7cfb\uff0c\u53c8\u662f\u7531\u4ec0\u4e48\u673a\u5236\u6240\u4ecb\u5bfc\u7684\u5462\uff1f<\/p>\n \u8fd9\u4e00\u7cfb\u5217\u7591\u95ee\u5728\u5148\u524d\u7684\u7814\u7a76\u4e2d\u5e76\u6ca1\u6709\u88ab\u5145\u5206\u89e3\u7b54[3-6]\uff0c\u8fd9\u8ba9\u63a2\u7d22\u996e\u9152\u4e0e\u8ba4\u77e5\u529f\u80fd\u4e4b\u95f4\u7684\u5173\u7cfb\u663e\u5f97\u9887\u4e3a\u5fc5\u8981\u3002<\/p>\n \u6700\u8fd1\u4e00\u9879\u76f8\u5173\u7814\u7a76\u53ca\u5176\u8bc4\u8bba\u53d1\u8868\u5728\u4e86\u8457\u540d\u533b\u5b66\u671f\u520aBMJ\u4e0a[7-9]\u3002\u8fd9\u9879\u7814\u7a76\u5162\u5162\u4e1a\u4e1a\u627e\u4e86\u8fd11\u4e07\u4eba\uff0c\u52e4\u52e4\u6073\u6073\u89c2\u5bdf\u4e8623\u5e74\uff0c\u5c31\u4e3a\u8bc1\u660e\u4e00\u4ef6\u4e8b\u7ed9\u4f60\u770b\u2014\u2014\u559d\u9152\u559d\u592a\u591a\uff0c\u4f1a\u628a\u4eba\u559d\u50bb\uff01<\/p>\n \u8001\u53cb\u76f8\u805a\u603b\u7231\u559d\u4e0a\u4e09\u4e24\u676f\uff1f\u5c0f\u5fc3\u559d\u592a\u591a\uff0c\u4ee5\u540e\u8001\u670b\u53cb\u90fd\u4e0d\u8ba4\u8bc6\u4e86\u54df\uff01<\/p>\n \u8bc1\u636e<\/strong><\/p>\n \u559d\u592a\u591a\u9152\u4f1a\u628a\u4eba\u559d\u50bb\uff01<\/strong><\/p>\n \u8fd9\u9879\u53d1\u8868\u5728BMJ\u4e0a\u7684\u7814\u7a76\u57fa\u4e8eWhitehall II\u961f\u5217\u7684\u6570\u636e\u3002\u8fd9\u4e00\u7814\u7a76\u7eb3\u5165\u4e861\u4e07\u591a\u540d\u82f1\u56fd\u7684\u516c\u52a1\u5458\uff0c\u8fd9\u7fa4\u516c\u52a1\u5458\u57281985-88\u5e74\u7814\u7a76\u5f00\u59cb\u65f6\u8fd8\u662f35-55\u5c81\u7684\u53d4\u53d4\u963f\u59e8\uff0c\u4ece\u90a3\u65f6\u5019\u8d77\u7814\u7a76\u4eba\u5458\u5c31\u4e0d\u65ad\u5730\u968f\u8bbf\u4ed6\u4eec\u7684\u996e\u9152\u91cf\uff0c\u76f4\u52302015-16\u5e74\u8fd9\u7fa4\u53d4\u53d4\u963f\u59e8\u90fd\u53d8\u621063-86\u5c81\u7684\u7237\u7237\u5976\u5976\uff0c2017\u5e74\u7814\u7a76\u6b63\u5f0f\u7ed3\u675f\u65f6\u4e00\u5171\u968f\u8bbf\u4e868\u6b21\u3002<\/p>\n \u57281\u4e07\u591a\u540d\u516c\u52a1\u5458\u4e2d\uff0c\u8fd12000\u4eba\u6ca1\u80fd\u201c\u575a\u6301\u201d\u5230\u6700\u540e\uff0c\u4eb2\u773c\u770b\u7740\u8fd9\u7bc7\u6587\u7ae0\u51fa\u7089\u3002\u4e0d\u8fc7\uff0c\u201c\u575a\u6301\u201d\u5230\u73b0\u5728\u76849000\u591a\u540d\u7237\u7237\u5976\u5976\u4eec\u4e5f\u4e0d\u662f\u5404\u4e2a\u90fd\u80fd\u8bfb\u61c2\u8fd9\u7bc7\u6587\u7ae0\u4e86\u2014\u2014\u5728\u5e73\u5747\u968f\u8bbf\u4e8623\u5e74\u4e4b\u540e\uff0c\u5176\u4e2d\u6709397\u4eba\u60a3\u4e0a\u4e86\u75f4\u5446\u3002\u6b63\u662f\u4ed6\u4eec\uff0c\u8ba9\u6211\u4eec\u6709\u673a\u4f1a\u4e00\u7aa5\u996e\u9152\u4e0e\u75f4\u5446\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n \u7ed3\u679c\u663e\u793a\uff0c\u5e74\u9f84\u5927\u3001\u5973\u6027\u3001\u53d7\u6559\u80b2\u7a0b\u5ea6\u4f4e\u3001\u804c\u4e1a\u5730\u4f4d\u4f4e\u4e0e\u8f83\u5927\u7684\u75f4\u5446\u98ce\u9669\u6709\u5173\uff1b\u5973\u6027\u3001\u975e\u767d\u4eba\u4ee5\u53ca\u793e\u4f1a\u7ecf\u6d4e\u5730\u4f4d\u8f83\u4f4e\u7684\u4eba\u66f4\u53ef\u80fd\u6212\u9152\uff0c\u5176\u5fc3\u8840\u7ba1\u4ee3\u8c22\u6307\u6807\u66f4\u7cdf\u7cd5\u3002\u6bcf\u5468\u996e\u9152\u57281-14\u4e2a\u5355\u4f4d\uff081\u5355\u4f4d=10ml\/8g\u9152\u7cbe\uff09\u7684\u4eba\u66f4\u559c\u6b22\u559d\u8461\u8404\u9152\uff0c\u800c\u6bcf\u5468\u996e\u9152\u91cf\u572814\u4e2a\u5355\u4f4d\u4ee5\u4e0a\u7684\u4eba\u5219\u66f4\u504f\u7231\u5564\u9152\u3002<\/p>\n \u5c0f\u914c\u4e0d\u4e00\u5b9a\u6021\u60c5\uff1a\u559d\u5f97\u8d8a\u591a\uff0c\u4eba\u8d8a\u5bb9\u6613\u75f4\u5446[6]<\/p>\n \u7814\u7a76\u4e2d\uff0c\u6839\u636e\u82f1\u56fd\u7684\u996e\u9152\u6307\u5357[10]\u5c06\u8fd9\u4e9b\u4eba\u7fa4\u5206\u4e3a\u6212\u9152\u8005\u3001\u6bcf\u5468\u996e\u91521-14\u4e2a\u5355\u4f4d\u7684\u9002\u91cf\u996e\u9152\u8005\u4ee5\u53ca\u6bcf\u5468\u996e\u9152\u8d85\u8fc714\u4e2a\u5355\u4f4d\u7684\u8fc7\u91cf\u996e\u9152\u8005\u3002\u5728\u8c03\u6574\u4e86\u5404\u9879\u56e0\u7d20\u4e4b\u540e\u53d1\u73b0\uff0c\u5728\u8fc7\u91cf\u996e\u9152\u7684\u4eba\u7fa4\u4e2d\uff0c\u4e2d\u5e74\u65f6\u671f\u6bcf\u5468\u996e\u9152\u91cf\u6bcf\u589e\u52a07\u4e2a\u5355\u4f4d\uff0c\u5176\u8001\u5e74\u671f\u75f4\u5446\u98ce\u9669\u5c31\u4f1a\u8f83\u9002\u91cf\u996e\u9152\u8005\u589e\u52a018%\uff08HR 1.18\uff0c95%CI 1.04-1.4\uff09\u300250\u5c81\u300160\u5c81\u300170\u5c81\uff0c\u5168\u7a0b\u65e0\u6b7b\u89d2\u5730\u8ba9\u4eba\u66f4\u5bb9\u6613\u75f4\u5446\u3002<\/p>\n \u8bc4\u4ef7\u9152\u7cbe\u4f9d\u8d56\u7a0b\u5ea6\u7684CAGE\u8bc4\u5206\u6ee1\u5206\u4e3a4\u5206\uff0c\u5206\u6570\u8d8a\u9ad8\u4ee3\u8868\u5bf9\u9152\u7cbe\u8d8a\u6709\u4f9d\u8d56[11]\uff0c\u5176\u5347\u9ad8\u4e0e\u75f4\u5446\u98ce\u9669\u4e5f\u663e\u8457\u76f8\u5173\u3002\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u8bc4\u5206\u57282\u5206\u4ee5\u4e0a\u7684\u996e\u9152\u8005\u4e0e0\u5206\u7684\u53c2\u4e0e\u8005\u76f8\u6bd4\uff0c\u75f4\u5446\u98ce\u9669\u51e0\u4e4e\u7ffb\u756a\uff08HR 1.98\uff0c95%CI 1.15-3.38\uff09\u3002<\/p>\n \u5982\u679c\u66fe\u6709\u9152\u7cbe\u76f8\u5173\u75be\u75c5\u5165\u9662\u7ecf\u5386\uff0c\u663e\u7136\u4e5f\u4ee3\u8868\u53c2\u4e0e\u8005\u66f4\u7231\u559d\u9152\uff0c\u53ea\u8981\u6709\u8fc71\u6b21\u8fd9\u6837\u7684\u7ecf\u5386\uff0c\u90a3\u4e48\u4ed6\u7684\u75f4\u5446\u98ce\u9669\u5c31\u4f1a\u63a5\u8fd1\u522b\u4eba\u76843\u500d\uff08HR 2.95\uff0c95%CI 1.85-4.71\uff09\u3002\u663e\u7136\uff0c\u6bcf\u5468\u8d85\u8fc714\u5355\u4f4d\u7684\u8fc7\u91cf\u996e\u9152\u53ef\u80fd\u4f1a\u5e26\u6765\u795e\u7ecf\u6bd2\u6027\u3002<\/p>\n \u53e6\u5916\uff0c\u7814\u7a76\u8fd8\u63d0\u793a\u60f3\u901a\u8fc7\u5065\u5eb7\u7684\u751f\u6d3b\u65b9\u5f0f\u6765\u907f\u514d\u8fc7\u91cf\u996e\u9152\u7684\u5371\u5bb3\u53ea\u4e0d\u8fc7\u662f\u676f\u6c34\u8f66\u85aa\u3002\u4e0d\u8fc7\u795e\u5947\u7684\u662f\uff0c\u5b8c\u5168\u6212\u9152\u8005\u7684\u98ce\u9669\uff0c\u75f4\u5446\u98ce\u9669\u8fd8\u662f\u4f1a\u8f83\u9002\u91cf\u996e\u9152\u8005\u66f4\u9ad8\uff08HR 1.45\uff0c95%CI 1.12-1.86\uff09\u3002<\/p>\n \u996e\u9152\u91cf\u4e0e\u75f4\u5446\u98ce\u9669\u4e4b\u95f4\u7684\u5173\u7cfb\u867d\u7136\u5df2\u7ecf\u660e\u786e\uff0c\u4f46\u5176\u80cc\u540e\u7684\u673a\u5236\u5374\u8fd8\u662f\u4e00\u4e2a\u8c1c\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63a2\u7d22\u8fde\u4e2a\u80cc\u540e\u7684\u673a\u5236\uff0c\u7814\u7a76\u4eba\u5458\u786e\u5b9a\u4e865\u79cd\u996e\u9152\u53d8\u5316\u8f68\u8ff9\uff0c\u5305\u62ec\u957f\u671f\u6212\u9152\u8005\u3001\u996e\u7528\u91cf\u51cf\u5c11\u3001\u957f\u671f\u9002\u91cf\u996e\u9152\u3001\u996e\u7528\u91cf\u589e\u52a0\u548c\u957f\u671f\u8fc7\u91cf\u996e\u9152\u3002<\/p>\n \u7ed3\u679c\u53d1\u73b0\uff0c\u4e0e\u957f\u671f\u9002\u91cf\u996e\u9152\u7684\u4eba\u7fa4\u76f8\u6bd4\uff0c\u957f\u671f\u6212\u9152\u8005\uff08HR 1.67\uff0c95%CI 1.26-2.23\uff09\u3001\u996e\u7528\u91cf\u51cf\u5c11\uff08HR 1.50\uff0c95%CI 1.04-2.16\uff09\u3001\u957f\u671f\u8fc7\u91cf\u996e\u9152\u8005\uff08HR 1.39\uff0c95%CI 1.01-1.92\uff09\u7684\u75f4\u5446\u98ce\u9669\u5747\u4f1a\u589e\u52a0\u3002<\/p>\n \u800c\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u663e\u793a\uff0c\u5fc3\u8840\u7ba1\u4ee3\u8c22\u75be\u75c5\u53ef\u80fd\u662f\u9690\u85cf\u5728\u996e\u9152\u91cf\u559d\u75f4\u5446\u98ce\u9669\u4e4b\u95f4\u7684\u4e2d\u4ecb\u8005\u3002\u5728\u6ca1\u6709\u5fc3\u8840\u7ba1\u4ee3\u8c22\u75be\u75c5\u7684\u4eba\u7fa4\u4e2d\uff0c\u957f\u671f\u6212\u9152\u8005\u7684\u75f4\u5446\u98ce\u9669\u5e76\u6ca1\u6709\u5347\u9ad8\uff08HR 1.33\uff0c95%CI 0.88-2.02\uff09\u3002\u4f17\u6240\u5468\u77e5\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u7cd6\u5c3f\u75c5\u53ef\u80fd\u4f1a\u589e\u52a0\u75f4\u5446\u7684\u98ce\u9669[12\uff0c13]\u3002\u56e0\u6b64\uff0c\u5728\u6574\u4f53\u7684\u6212\u9152\u4eba\u7fa4\u4e2d\uff0c\u53ef\u80fd\u7531\u4e8e\u5fc3\u8840\u7ba1\u4ee3\u8c22\u75be\u75c5\u7684\u5b58\u5728\uff0c\u5bfc\u81f4\u4e86\u75f4\u5446\u98ce\u9669\u7684\u5347\u9ad8\uff08HR 1.47\uff0c95%CI 1.15-1.89\uff09\u2014\u2014\u96be\u9053\u8981\u559d\u9152\u4fdd\u62a4\u5fc3\u8840\u7ba1\u6765\u9632\u75f4\u5446\uff1f<\/p>\n \u867d\u7136\u996e\u9152\u80fd\u4e0d\u80fd\u901a\u8fc7\u4fdd\u62a4\u5fc3\u8840\u7ba1\u9632\u75f4\u5446\u8fd8\u6709\u7591\u95ee\uff0c\u4f46\u8fc7\u91cf\u996e\u9152\u4f24\u8eab\u8fd8\u662f\u6709\u5b9e\u9524\u3002\u5728\u8fc7\u91cf\u996e\u9152\u8005\u4e2d\uff0c\u75f4\u5446\u98ce\u9669\u7684\u589e\u52a0\u4e0e\u662f\u5426\u8003\u8651\u5fc3\u8840\u7ba1\u4ee3\u8c22\u56e0\u7d20\u65e0\u5173\uff08HR 1.16 vs 1.17\uff09\uff0c\u7684\u7684\u786e\u786e\u662f\u6bcf\u559d\u4e00\u53e3\u9152\uff0c\u5c31\u4f1a\u79bb\u75f4\u5446\u66f4\u8fd1\u4e00\u70b9\u3002<\/p>\n \u5efa\u8bae<\/strong><\/p>\n \u6ca1\u4e8b\u513f\u8fd8\u662f\u60a0\u7740\u70b9\u513f\u2026<\/strong><\/p>\n \u4e00\u4f1a\u513f\u8bf4\u559d\u592a\u591a\u9152\u75f4\u5446\u98ce\u9669\u8e6d\u8e6d\u5f80\u4e0a\u7a9c\uff0c\u4e00\u4f1a\u513f\u53c8\u8bf4\u5b8c\u5168\u4e0d\u559d\u98ce\u9669\u4e5f\u4f1a\u589e\u52a0\uff0c\u90a3\u4e48\u6211\u5230\u5e95\u559d\u4e0d\u559d\u5566\uff01<\/p>\n \u7eb5\u89c2\u5168\u7403\u6307\u5357\uff0c\u53ea\u6709\u9650\u5236\u996e\u9152\u91cf\uff0c\u6ca1\u6709\u9f13\u52b1\u5927\u5bb6\u559d\u9152\u7684\uff0c\u66f4\u6ca1\u6709\u9f13\u52b1\u901a\u8fc7\u9002\u91cf\u996e\u9152\u9632\u75f4\u5446\u7684[14]\u3002\u8fd9\u4e00\u7814\u7a76\u7684\u7b2c\u4e00\u4f5c\u8005\u3001\u6cd5\u56fd\u56fd\u7acb\u5065\u5eb7\u4e0e\u533b\u5b66\u7814\u7a76\u6240\u6d41\u884c\u75c5\u5b66\u5bb6\u3001\u4f26\u6566\u5927\u5b66\u5b66\u9662\u526f\u7814\u7a76\u5458S\u00e9verine Sabia\u540c\u6837\u4e0d\u9f13\u52b1\u5927\u5bb6\u996e\u9152[9]\u3002<\/p>\n \u7814\u7a76\u8ba4\u4e3a\uff0c\u5e94\u5f53\u4e0b\u8c03\u6307\u5357\u63a8\u8350\u7684\u996e\u9152\u4e0a\u9650\u3002\u524d\u6bb5\u65f6\u95f4\uff0c\u82f1\u56fd\u7684\u996e\u9152\u6307\u5357[14]\u5c31\u5c06\u7537\u6027\u7684\u6bcf\u5468\u996e\u9152\u91cf\u9650\u5236\u5230\u4e8614\u4e2a\u5355\u4f4d\uff08140ml\/112g\u9152\u7cbe\uff09\u3002\u8fd9\u4e00\u7814\u7a76\u4e5f\u652f\u6301\u8fd9\u4e00\u8c03\u6574\uff0c\u8d85\u8fc7\u8fd9\u4e00\u6c34\u5e73\u7684\u9152\u7cbe\u6444\u5165\u5c06\u4f1a\u901a\u8fc7\u4e00\u7cfb\u5217\u7684\u9014\u5f84\u635f\u4f24\u5927\u8111\uff0c\u5305\u62ec\u5bfc\u81f4\u5927\u8111\u8425\u517b\u4e0d\u826f\uff0c\u4e59\u9187\u7684\u76f4\u63a5\u795e\u7ecf\u6bd2\u6027\uff0c\u589e\u52a0\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u538b\u3001\u4e2d\u98ce\u7684\u53d1\u75c5\u7387\u7b49[15-19]\u3002<\/p>\n \u867d\u7136\u9002\u91cf\u996e\u9152\u53ef\u80fd\u5bf9\u5fc3\u8840\u7ba1\u7cfb\u7edf\u6709\u4e00\u5b9a\u7684\u76ca\u5904\uff0c\u4f46\u76f8\u6bd4\u4e8e\u8fd9\u4e9b\u53ef\u80fd\u7684\u76ca\u5904\uff0c\u996e\u9152\u7684\u5371\u5bb3\u66f4\u5927\u2014\u2014\u5c0f\u914c\u4e0d\u4e00\u5b9a\u6021\u60c5\uff0c\u4f46\u5927\u996e\u4e00\u5b9a\u4f24\u8eab\u2014\u2014\u996e\u9152\u65e9\u5df2\u88ab\u8bc1\u660e\u4e0e\u4e00\u7cfb\u5217\u7684\u6162\u6027\u75c5\u76f8\u5173\uff0c\u5305\u62ec\u764c\u75c7\u3001\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u809d\u786c\u5316\u7b49\u7b49\u3002\u540c\u65f6\uff0c\u996e\u9152\u8fd8\u8981\u4e3a\u5168\u7403\u8fd14%\u7684\u6b7b\u4ea1\u4ee5\u53ca4.6%\u7684\u6b8b\u75be\u8c03\u6574\u751f\u547d\u5e74\u7684\u8d1f\u8d23\uff0c\u5176\u5bf9\u4e8e\u5065\u5eb7\u603b\u4f53\u4e0a\u6709\u5bb3[1]\u3002<\/p>\n \u996e\u9152\u589e\u52a0\u4e00\u7cfb\u5217\u75be\u75c5\u7684\u8d1f\u62c5[1]<\/p>\n \u53cd\u89c2\u4e2d\u56fd\u7684\u996e\u9152\u6307\u5357\uff0c\u5176\u996e\u9152\u9650\u5236\u4e3a\u5973\u602715g\/d\u8f83\u82f1\u56fd12g\/d\u66f4\u9ad8\uff1b\u7537\u6027\u9650\u5236\u4e3a25g\/d\u662f\u82f1\u56fd\u76842\u500d\u8fd8\u8981\u591a[14]\u3002\u7136\u800c\uff0c\u5f88\u65e9\u5c31\u53d1\u73b0\u4e2d\u56fd\u3001\u65e5\u672c\u3001\u97e9\u56fd\u7b49\u56fd\u7684\u4e1c\u4e9a\u4eba\u7fa4\u5176\u9152\u7cbe\u4ee3\u8c22\u80fd\u529b\u8f83\u5dee\uff0c\u5176\u6240\u5e26\u6765\u7684\u989c\u9762\u6f6e\u7ea2\u7b49\u6025\u6027\u8fc7\u654f\u53cd\u5e94\u672c\u5c31\u53ef\u80fd\u662f\u4e3a\u4e86\u9632\u6b62\u6211\u4eec\u8fc7\u5ea6\u996e\u9152\u7684\u4fdd\u62a4\u673a\u5236[20]\u3002\u5728\u8fd9\u6837\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd9\u4e00\u63a8\u8350\u663e\u7136\u5e76\u4e0d\u5341\u5206\u5408\u9002\u3002<\/p>\n \u6240\u4ee5\uff0c\u6211\u7a76\u7adf\u8be5\u4e0d\u8be5\u6765\u4e00\u70b9\uff1f<\/p>\n \u7814\u7a76\u3001\u7efc\u8ff0\u3001\u6307\u5357\u3001\u8bc4\u8bba\u5728\u8fd9\u4e00\u95ee\u9898\u4e0a\u7684\u89c2\u70b9\u9887\u4e3a\u4e00\u81f4\uff1a\u4e0d\u559d\u9152\u7684\u4eba\u5343\u4e07\u522b\u627e\u8fd9\u4e2a\u501f\u53e3\u5f00\u59cb\u559d\u9152\uff0c\u559d\u591a\u4e86\u7684\u4eba\u8d76\u7d27\u522b\u559d\u90a3\u4e48\u591a\uff01<\/p>\n \u53c2\u8003\u6587\u732e\uff1a<\/p>\n [1]Rehm J\uff0cMathers C\uff0cPopova S\uff0cet al.(2009).Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders.Lancet 2009;373\uff1a2223-33.doi\uff1a10.1016\/S0140-6736(09)60746-7.<\/p>\n [2]Prince M\uff0cGuerchet M\uff0cPrina M.(2015).The Epidemiology and Impact of Dementia\uff1aCurrent State and Future Trends.World Health Organization\uff0c2015.<\/p>\n [3]Anstey KJ\uff0cMack HA\uff0cCherbuin N.(2009).Alcohol consumption as a risk factor for dementia and cognitive decline\uff1ameta-analysis of prospective studies.Am J Geriatr Psychiatry 2009;17\uff1a542-55.doi\uff1a10.1097\/JGP.0b013e3181a2fd07.<\/p>\n [4]Panza F\uff0cFrisardi V\uff0cSeripa D\uff0cet al.(2012).Alcohol consumption in mild cognitive impairment and dementia\uff1aharmful or neuroprotective\uff1fInt J Geriatr Psychiatry 2012;27\uff1a1218-38.doi\uff1a10.1002\/gps.3772.<\/p>\n [5]Xu W\uff0cWang H\uff0cWan Y\uff0cet al.(2017).Alcohol consumption and dementia risk\uff1aa dose-response meta-analysis of prospective studies.Eur J Epidemiol 2017;32\uff1a31-42.doi\uff1a10.1007\/s10654-017-0225-3.<\/p>\n [6]Topiwala A\uff0cAllan CL\uff0cValkanova V\uff0cet al.(2017).Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline\uff1alongitudinal cohort study.BMJ 2017;357\uff1aj2353 doi\uff1a10.1136\/bmj.j2353.<\/p>\n [7]Sabia S\uff0cFayosse A\uff0cDumurgier J\uff0cet al.(2018).Alcohol consumption and risk of dementia\uff1a23 year follow-up of Whitehall II cohort study.BMJ 2018;362\uff1ak2927.doi\uff1a10.1136\/bmj.k2927.<\/p>\n [8]Yasar S.(2018).Relation between alcohol consumption in midlife and dementia in late life.BMJ 2018;362\uff1ak3164 doi\uff1a10.1136\/bmj.k3164.<\/p>\n [9]Sabia S.S\u00e9verine Sabia\uff1aThe role of health behaviours in cognitive ageing.The BMJ Opinion\uff0cAugust 1 2018.Available at\uff1ahttps\uff1a\/\/blogs.bmj.com\/bmj\/2018\/08\/01\/severine-sabia-role-health-behaviours-cognitive-ageing\/Last assessed on 2018-08-03.<\/p>\n [10]UK Chief Medical Officers.UK Chief Medical Officers\u2019Low Risk Drinking Guidelines 2016.<\/p>\n [11]Ewing JA.(1984).Detecting alcoholism.The CAGE questionnaire.JAMA 1984;252\uff1a1905-7.doi\uff1a10.1001\/jama.1984.03350140051025.<\/p>\n [12]Winblad B\uff0cAmouyel P\uff0cAndrieu S\uff0cet al.(2016).Defeating Alzheimer\u2019s disease and other dementias\uff1aa priority for European science and society.Lancet Neurol 2016;15\uff1a455-532.doi\uff1a10.1016\/S1474-4422(16)00062-4.<\/p>\n [13]Biessels GJ\uff0cStrachan MW\uff0cVisseren FL\uff0cet al.(2014).Dementia and cognitive decline in type 2 diabetes and prediabetic stages\uff1atowards targeted interventions.Lancet Diabetes Endocrinol 2014;2\uff1a246-55.doi\uff1a10.1016\/S2213-8587(13)70088-3.<\/p>\n [14]International allience for responsible drinking.Drinking guidelines\uff1aGeneral population[updated January 2018].Available at\uff1awww.iard.org\/policy-tables\/drinking-guidelines-general-population\/Last accessed on 2018-08-03.<\/p>\n [15]Zahr NM\uff0cKaufman KL\uff0cHarper CG.(2011).Clinical and pathological features of alcohol-related brain damage.Nat Rev Neurol 2011;7\uff1a284-94.doi\uff1a10.1038\/nrneurol.2011.42.<\/p>\n [16]Knott C\uff0cBell S\uff0cBritton A.(2015).Alcohol Consumption and the Risk of Type 2 Diabetes\uff1aA Systematic Review and Dose-Response Meta-analysis of More Than 1.9 Million Individuals From 38 Observational Studies.Diabetes Care 2015;38\uff1a1804-12.doi\uff1a10.2337\/dc15-0710.<\/p>\n [17]Miller PM\uff0cAnton RF\uff0cEgan BM\uff0cet al.(2005).Excessive alcohol consumption and hypertension\uff1aclinical implications of current research.J Clin Hypertens(Greenwich)2005;7\uff1a346-51.doi\uff1a10.1111\/j.1524-6175.2004.04463.x.<\/p>\n [18]Mostofsky E\uff0cChahal HS\uff0cMukamal KJ\uff0cet al.(2016).Alcohol and Immediate Risk of Cardiovascular Events\uff1aA Systematic Review and Dose-Response Meta-Analysis.Circulation 2016;133\uff1a979-87.doi\uff1a10.1161\/CIRCULATIONAHA.115.019743.<\/p>\n [19]Zhang C\uff0cQin YY\uff0cChen Q\uff0cet al.(2014).Alcohol intake and risk of stroke\uff1aa dose-response meta-analysis of prospective studies.Int J Cardiol 2014;174\uff1a669-77.doi\uff1a10.1016\/j.ijcard.2014.04.225.<\/p>\n [20]Goedde HW\uff0cAgarwal DP.(1987).Polymorphism of aldehyde dehydrogenase and alcohol sensitivity.Enzyme.1987;37(1-2)\uff1a29-44.<\/p>\n","protected":false},"excerpt":{"rendered":" \u7591\u95ee\uff1a\u6240\u8c13\u9002\u91cf\u7a76\u7adf\u662f\u591a\u5c11\uff1f\u8bc1\u636e\uff1a\u559d\u592a\u591a\u9152\u4f1a\u628a\u4eba\u559d\u50bb\uff01\u5efa\u8bae\uff1a\u6ca1\u4e8b\u513f\u8fd8\u662f\u60a0\u7740\u70b9\u513f\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[648,254,794],"_links":{"self":[{"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/posts\/20668"}],"collection":[{"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/comments?post=20668"}],"version-history":[{"count":1,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/posts\/20668\/revisions"}],"predecessor-version":[{"id":20670,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/posts\/20668\/revisions\/20670"}],"wp:attachment":[{"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/media?parent=20668"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/categories?post=20668"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/tags?post=20668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}