\u751f\u6d3b\u4e2d\u4e00\u76f4\u6d41\u4f20\u7740\u201c\u6bcf\u99107\u5206\u9971\uff0c\u5065\u5eb7\u6d3b\u5230\u8001\u201d\u7684\u8bf4\u6cd5\uff0c\u4f46\u5bf9\u4e8e\u7f8e\u98df\u7684\u8ffd\u6c42\u662f\u4eba\u4eec\u4e0e\u751f\u4ff1\u6765\u7684\uff0c\u7f8e\u98df\u5728\u524d\uff0c\u98df\u5ba2\u4eec\u5f80\u5f80\u90fd\u662f\u5403\u5f97\u5c3d\u5174\uff0c\u5403\u5f97\u8fc7\u763e\uff01\u4f46\u7814\u7a76\u8bc1\u660e\uff0c\u514b\u5236\u662f\u4e00\u79cd\u667a\u6167\uff0c\u5408\u7406\u9002\u91cf\u7684\u9650\u5236\u996e\u98df\uff0c\u5f80\u5f80\u80fd\u591f\u6d3b\u5f97\u66f4\u5065\u5eb7\uff0c\u51cf\u5c11\u75be\u75c5\u7684\u53d1\u751f\u6982\u7387\u3002\u90a3\u751f\u6d3b\u4e2d\u54ea\u4e9b\u75be\u75c5\u53ef\u80fd\u662f\u201c\u6491\u201d\u51fa\u6765\u7684\u5462\uff1f<\/p>\n
\u4e00\u3001\u8fd9\u4e94\u79cd\u75c5\u53ef\u80fd\u662f\u201c\u6491\u201d\u51fa\u6765\u7684<\/p>\n
1\u3001 \u80c3\u75c5<\/p>\n
\u6444\u5165\u8fc7\u591a\u98df\u7269\u4f1a\u589e\u52a0\u80c3\u7684\u8d1f\u62c5\uff0c\u53ef\u80fd\u5bfc\u81f4\u80c3\u90e8\u4e0d\u9002\uff0c\u5982\u80c3\u80c0\u3001\u80c3\u75db\u548c\u6d88\u5316\u4e0d\u826f\u7b49\u95ee\u9898\uff0c\u4e25\u91cd\u65f6\u751a\u81f3\u53ef\u5f15\u53d1\u80c3\u9178\u9006\u6d41\u3001\u80c3\u6e83\u75a1\u7b49\u75be\u75c5\u3002\u6b64\u5916\uff0c\u9ad8\u8102\u80aa\u3001\u9ad8\u76d0\u548c\u8f9b\u8fa3\u98df\u7269\u7684\u8fc7\u5ea6\u6444\u5165\u4e5f\u53ef\u80fd\u52a0\u91cd\u80c3\u708e\u548c\u80c3\u708e\u7b49\u75be\u75c5\u3002<\/p>\n
2\u3001 \u5fc3\u6897<\/p>\n
\u9ad8\u80c6\u56fa\u9187\u3001\u9ad8\u8102\u80aa\u3001\u9ad8\u76d0\u548c\u9ad8\u7cd6\u7684\u996e\u98df\u4e60\u60ef\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\u589e\u52a0\u5bc6\u5207\u76f8\u5173\u3002\u8fc7\u91cf\u996e\u98df\u53ef\u80fd\u5bfc\u81f4\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff0c\u4f7f\u8840\u7ba1\u58c1\u9010\u6e10\u53d8\u539a\uff0c\u8840\u7ba1\u8154\u53d8\u7a84\uff0c\u6700\u7ec8\u5bfc\u81f4\u5fc3\u808c\u6897\u6b7b\u3002\u6b64\u5916\uff0c\u80a5\u80d6\u4e5f\u4f1a\u589e\u52a0\u5fc3\u810f\u8d1f\u8377\uff0c\u589e\u52a0\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u60a3\u75c5\u98ce\u9669\u3002<\/p>\n
3\u3001 \u80a5\u80d6\u75c7<\/p>\n
\u80a5\u80d6\u75c7\u6307\u4f53\u8102\u80aa\u7d2f\u79ef\u8fc7\u591a\u800c\u5bf9\u5065\u5eb7\u9020\u6210\u8d1f\u9762\u5f71\u54cd\u7684\u8eab\u4f53\u72b6\u6001\uff0c\u8fc7\u91cf\u996e\u98df\u662f\u80a5\u80d6\u75c7\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\uff0c\u5f53\u8fc7\u591a\u7684\u5361\u8def\u91cc\u88ab\u6444\u5165\u4f53\u5185\uff0c\u5269\u4f59\u80fd\u91cf\u88ab\u50a8\u5b58\u4e3a\u8102\u80aa\uff0c\u4fbf\u4f1a\u5bfc\u81f4\u4f53\u91cd\u589e\u52a0\u3002\u957f\u671f\u8fc7\u5ea6\u996e\u98df\u4f1a\u5f15\u53d1\u6162\u6027\u80fd\u91cf\u8fc7\u5269\uff0c\u5bfc\u81f4\u80a5\u80d6\uff0c\u8fdb\u800c\u589e\u52a0\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u538b\u7b49\u75be\u75c5\u7684\u98ce\u9669\u3002<\/p>\n
4\u3001 \u7cd6\u5c3f\u75c5<\/p>\n
\u8fc7\u91cf\u996e\u98df\uff0c\u5c24\u5176\u662f\u9ad8\u7cd6\u996e\u98df\uff0c\u4e0e2\u578b\u7cd6\u5c3f\u75c5\u7684\u53d1\u75c5\u5bc6\u5207\u76f8\u5173\u3002\u9ad8\u8840\u7cd6\u72b6\u6001\u53ef\u80fd\u5bfc\u81f4\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u8fdb\u800c\u5f71\u54cd\u80f0\u5c9b\u7d20\u7684\u6b63\u5e38\u5206\u6ccc\u548c\u7cd6\u4ee3\u8c22\u3002\u957f\u671f\u9ad8\u8840\u7cd6\u72b6\u6001\u4f1a\u635f\u5bb3\u8840\u7ba1\u3001\u795e\u7ecf\u548c\u591a\u4e2a\u5668\u5b98\uff0c\u589e\u52a0\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u80be\u75c5\u3001\u89c6\u7f51\u819c\u75c5\u53d8\u7b49\u5e76\u53d1\u75c7\u7684\u98ce\u9669\u3002<\/p>\n
5\u3001 \u80be\u75c5<\/p>\n
\u9ad8\u76d0\u548c\u9ad8\u86cb\u767d\u8d28\u7684\u996e\u98df\u4e60\u60ef\u4e0e\u80be\u810f\u5065\u5eb7\u4e0d\u826f\u76f8\u5173\u3002\u6444\u5165\u8fc7\u91cf\u7684\u76d0\u5206\u53ef\u80fd\u5bfc\u81f4\u8840\u538b\u5347\u9ad8\uff0c\u589e\u52a0\u80be\u810f\u7684\u8d1f\u62c5\u3002\u9ad8\u76d0\u996e\u98df\u8fd8\u4f1a\u5f15\u8d77\u4f53\u5185\u94a0\u6c34\u5e73\u589e\u52a0\uff0c\u4ece\u800c\u5bfc\u81f4\u8840\u5bb9\u91cf\u589e\u52a0\uff0c\u8fdb\u800c\u589e\u52a0\u5fc3\u810f\u7684\u8d1f\u8377\uff0c\u5bfc\u81f4\u9ad8\u8840\u538b\u7684\u98ce\u9669\u589e\u52a0\u3002<\/p>\n
\u6b64\u5916\uff0c\u6444\u5165\u8fc7\u591a\u7684\u86cb\u767d\u8d28\u53ef\u80fd\u589e\u52a0\u80be\u5c0f\u7ba1\u7684\u8d1f\u62c5\uff0c\u5c24\u5176\u662f\u5bf9\u4e8e\u5df2\u7ecf\u5b58\u5728\u80be\u810f\u75be\u75c5\u7684\u4eba\u800c\u8a00\uff0c\u53ef\u80fd\u52a0\u901f\u80be\u810f\u529f\u80fd\u4e0b\u964d\u3002<\/p>\n
\u4e8c\u3001\u9650\u5236\u996e\u98df\u53ef\u4ee5\u6d3b\u5f97\u66f4\u5065\u5eb7<\/p>\n
1\u3001\u996d\u91cf\u51cf\u5c111\/3\uff0c\u5bff\u547d\u5ef6\u957f20\u5e74<\/p>\n
\u4e00\u9879\u6765\u81ea\u7f8e\u56fd\u56fd\u5bb6\u8870\u8001\u7814\u7a76\u6240\uff08NIA\uff09\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u6bcf\u65e5\u51cf\u5c11\u98df\u7269\u6444\u5165\u91cf\u8fbe\u52301\/3\uff0c\u53ef\u4ee5\u5c06\u7334\u5b50\u7684\u5e73\u5747\u5bff\u547d\u5ef6\u957f20\u5e74\uff0c\u4e14\u5728\u5916\u8c8c\u548c\u884c\u4e3a\u4e0a\u6ca1\u6709\u51fa\u73b0\u660e\u663e\u7684\u8870\u8001\u8ff9\u8c61\u3002<\/p>\n
\u5728\u8fd9\u9879\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u964d\u4f4e\u98df\u7269\u6444\u5165\u91cf\u8fd8\u80fd\u591f\u663e\u8457\u964d\u4f4e\u7334\u5b50\u60a3\u4e0a\u764c\u75c7\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98ce\u9669\uff0c\u98ce\u9669\u964d\u4f4e\u5e45\u5ea6\u8d85\u8fc750%\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u672a\u53d7\u9650\u5236\u6444\u98df\u7684\u7334\u5b50\u6b7b\u4ea1\u98ce\u9669\u5219\u9ad8\u51fa\u4e86\u7ea63\u500d\u3002<\/p>\n
\u57fa\u4e8e\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\uff0c\u7814\u7a76\u4eba\u5458\u5f97\u51fa\u7ed3\u8bba\uff0c\u8fd9\u4e9b\u53d1\u73b0\u6697\u793a\u4e86\u7075\u957f\u7c7b\u52a8\u7269\u7684\u8870\u8001\u8fc7\u7a0b\u662f\u53ef\u4ee5\u901a\u8fc7\u63a7\u5236\u624b\u6bb5\u52a0\u4ee5\u5e72\u9884\u7684\u3002<\/p>\n
\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u5206\u6790\u6307\u51fa\uff0c\u7531\u4e8e\u4eba\u7c7b\u4e0e\u7334\u5b50\u4e4b\u95f4\u5b58\u5728\u7740\u76f8\u4f3c\u7684\u57fa\u56e0\u7ec4\u6210\u548c\u8870\u8001\u65b9\u5f0f\uff0c\u56e0\u6b64\u5728\u67d0\u79cd\u7a0b\u5ea6\u4e0a\uff0c\u7075\u957f\u7c7b\u52a8\u7269\u4e0a\u7684\u7814\u7a76\u7ed3\u679c\u53ef\u80fd\u4e3a\u4eba\u7c7b\u8870\u8001\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u501f\u9274\u3002\u4ed6\u4eec\u5bc4\u5e0c\u671b\u4e8e\u672a\u6765\u53ef\u80fd\u53d1\u73b0\uff0c\u901a\u8fc7\u51cf\u5c11\u996e\u98df\u7684\u6444\u5165\u91cf\uff0c\u4e5f\u80fd\u591f\u5728\u4eba\u7c7b\u8eab\u4e0a\u53d6\u5f97\u7c7b\u4f3c\u7684\u8870\u8001\u5ef6\u7f13\u6548\u679c\u3002<\/p>\n
\u603b\u4e4b\uff0c\u8fd9\u9879\u7814\u7a76\u5728\u7075\u957f\u7c7b\u52a8\u7269\u8eab\u4e0a\u7684\u89c2\u5bdf\u7ed3\u679c\u4e3a\u7406\u89e3\u548c\u5e72\u9884\u8870\u8001\u8fc7\u7a0b\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\uff0c\u540c\u65f6\u4e5f\u4e3a\u672a\u6765\u9488\u5bf9\u4eba\u7c7b\u8870\u8001\u7684\u7814\u7a76\u548c\u5e72\u9884\u63d0\u4f9b\u4e86\u6709\u76ca\u7684\u542f\u793a\u3002<\/p>\n
2\u3001\u5e2e\u52a9\u9884\u9632\u80a5\u80d6<\/p>\n
2022\u5e744\u670821\u65e5\uff0c\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5357\u65b9\u533b\u9662\u7684\u5f20\u60e0\u6770\u6559\u6388\u5728\u6743\u5a01\u533b\u5b66\u6742\u5fd7\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08NEJM\uff09\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u91cd\u8981\u7684\u7814\u7a76\u8bba\u6587\uff0c\u8be5\u7814\u7a76\u8868\u660e\uff0c\u65e0\u8bba\u8fdb\u98df\u65f6\u95f4\u5982\u4f55\uff0c\u5c11\u5403\u624d\u662f\u5173\u952e\u7684\u51cf\u80a5\u7b56\u7565\u3002<\/p>\n
\u7814\u7a76\u4e2d\u5bf9\u6bd4\u4e86\u4e24\u79cd\u51cf\u80a5\u6a21\u5f0f\uff1a\u9650\u65f6\u996e\u98df\u548c\u5e38\u89c4\u80fd\u91cf\u9650\u5236\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8fd9\u4e24\u79cd\u6a21\u5f0f\u5728\u51cf\u91cd\u6548\u679c\u4e0a\u540c\u7b49\u6709\u6548\uff0c\u7136\u800c\u9650\u65f6\u996e\u98df\u6a21\u5f0f\u7684\u6210\u529f\u4e3b\u8981\u5f97\u76ca\u4e8e\u80fd\u91cf\u9650\u5236\u3002\u8fd9\u9879\u7814\u7a76\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u9650\u65f6\u996e\u98df\u4f5c\u4e3a\u4e00\u79cd\u5b89\u5168\u3001\u6709\u6548\u4e14\u53ef\u66ff\u4ee3\u7684\u80a5\u80d6\u7ba1\u7406\u65b9\u6cd5\u3002<\/p>\n
3\u3001\u6291\u5236\u6709\u5bb3\u708e\u75c7<\/p>\n
\u4e00\u9879\u53d1\u8868\u5728\u300aCell\u300b\u5b50\u520a\uff0c\u6765\u81ea\u8036\u9c81\u5927\u5b66\u7814\u7a76\u56e2\u961f\u7684\u8bba\u6587\u6307\u51fa\uff0c\u9002\u5ea6\u7684\u70ed\u91cf\u9650\u5236\u53ef\u80fd\u51cf\u5c11\u4e0e\u8870\u8001\u6709\u5173\u7684\u86cb\u767d\u8d28SPARC\u7684\u751f\u6210\uff0c\u4ece\u800c\u6291\u5236\u6709\u5bb3\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u5e76\u6709\u671b\u6539\u5584\u8001\u5e74\u4eba\u7684\u5065\u5eb7\u72b6\u51b5\uff0c\u8fdb\u800c\u5ef6\u957f\u4eba\u7c7b\u7684\u5065\u5eb7\u5bff\u547d\u3002<\/p>\n
\u7814\u7a76\u56e2\u961f\u5206\u6790\u4e86\u4e00\u4e2a\u540d\u4e3a\u201c\u51cf\u5c11\u80fd\u91cf\u6444\u5165\u7684\u957f\u671f\u6548\u679c\u7efc\u5408\u8bc4\u4ef7\uff08CALERIE\uff09\u201d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5728\u8fd9\u9879\u8bd5\u9a8c\u4e2d\uff0c\u90e8\u5206\u53c2\u4e0e\u8005\u5728\u4e24\u5e74\u5185\u51cf\u5c11\u4e8614%\u7684\u70ed\u91cf\u6444\u5165\u3002\u968f\u540e\uff0c\u7814\u7a76\u56e2\u961f\u5bf9\u8fd9\u4e9b\u53c2\u4e0e\u8005\u8fdb\u884c\u4e86\u957f\u671f\u7684\u8ffd\u8e2a\uff0c\u4ee5\u8bc4\u4f30\u8fd9\u79cd\u5065\u5eb7\u5e72\u9884\u7684\u6548\u679c\u3002<\/p>\n
\u7ed3\u679c\u53d1\u73b0\uff0c\u7ecf\u8fc7\u4e00\u6bb5\u65f6\u95f4\u7684\u70ed\u91cf\u9650\u5236\u540e\uff0c\u53c2\u4e0e\u8005\u7684\u8102\u80aa\u7ec4\u7ec7\u4e2dSPARC\u7684\u8868\u8fbe\u660e\u663e\u51cf\u5c11\u3002\u8fd9\u4e2a\u86cb\u767d\u8d28\u4e0e\u80a5\u80d6\u3001\u7cd6\u5c3f\u75c5\u7b49\u5065\u5eb7\u95ee\u9898\u5bc6\u5207\u76f8\u5173\uff0c\u800c\u80a5\u80d6\u5219\u4f1a\u5bfc\u81f4SPARC\u86cb\u767d\u7684\u589e\u52a0\u3002<\/p>\n
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